Research on AI applications at ESA’s largest technical department range from AI powered personal assistants to knowledge graphs to neuromorphic computations and G&C algorithms powered by novel deep architectures and more. After giving a brief overview on various activities, this presentation will focus on a few cherry-picked developments exploring in depth novel results being consolidated and their connection with state-of the art AI research. We will thus touch upon geodesy, spacecraft guidance and control, eclipse computations, as well as the inverse design of materials and the use of neuromorphic hardware (event based cameras) and software (spiking neural networks) to increase the autonomy and efficiency of future spacecraft.